Publication date: Available online 22 October 2018
Source: Archives of Physical Medicine and Rehabilitation
Author(s): Andrea Polli, Kelly Ickmans, Lode Godderis, Jo Nijs
Abstract
Epigenetic mechanisms represent a link between the environment and gene function. Recent evidence shows how early-life stress, inflammation, and physical activity can influence gene expression through epigenetic mechanisms. Epigenetic changes – such as DNA methylation and microRNA interference – can be measured in humans and might soon become important biological markers. Epigenetic marks can accompany clinical assessment to measure the effectiveness of various interventions, such as exercise therapy.
In addition, epigenetics is improving the understanding of important underlying mechanisms related to the central nervous system, the opioidergic system, and stress responses. Epigenetics is covering a gap in our explanatory abilities and should be implemented to broaden the field of rehabilitation sciences, promote a mechanism-based clinical reasoning, and develop new treatments.
In the present review, we focused on epigenetic mechanisms related to pain, psychological factors such as fear and anxiety, and physical activity, translating relevant findings from these three different – yet related – areas of cardinal importance for clinicians.
from Rehabilitation via xlomafota13 on Inoreader https://ift.tt/2JgcrUR
via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.