Physical Activity, Television Viewing Time, and DNA Methylation in Peripheral Blood

Introduction Physical activity may affect health via DNA methylation. The epigenetic influences of sedentary behaviours such as television viewing are unknown. We performed a genome-wide study of DNA methylation in peripheral blood in relation to physical activity and television viewing time. Methods DNA methylation was measured using the Illumina Infinium HumanMethylation450K BeadChip array in blood samples collected at baseline (N=5,513) and follow-up (N=1,249) from participants in the Melbourne Collaborative Cohort Study. At baseline, times/week of leisure-time physical activity was self-reported. At follow-up, the International Physical Activity Questionnaire was used to assess MET-hours/week of total and leisure-time physical activity, and hours/day of television viewing time. Linear mixed models were used to assess associations between the physical activity and television viewing measures and DNA methylation at individual CpG sites, adjusted for potential confounders and batch effects. Results At follow-up, total physical activity was associated with DNA methylation at cg10266336 (P=6.0x10-9), annotated to the SAA2 gene. Weaker evidence of associations (P

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