Non-invasive brain stimulation in the modulation of cerebral blood flow after stroke: a systematic review of Transcranial Doppler studies

Publication date: Available online 25 October 2018

Source: Clinical Neurophysiology

Author(s): Pooja C Iyer, Sangeetha Madhavan

Abstract

Objective

Non-invasive brain stimulation (NIBS), such as repetitive TMS (rTMS) and transcranial direct current stimulation (tDCS), are promising neuromodulatory priming techniques to promote task-specific functional recovery after stroke. Despite promising results, clinical application of NIBS has been limited by high inter-individual variability. We propose that there is a possible influence of neuromodulation on cerebral blood flow (CBF), as neurons are spatially and temporally related to blood vessels. Transcranial Doppler (TCD), a clinically available non-invasive diagnostic tool, allows for evaluation of CBF velocity (CBFv). However, little is known about the role of neuromodulation on CBFv.

Methods

A systematic review of literature to understand the effects of NIBS on CBFv using TCD in stroke was conducted.

Results

Twelve studies fit our inclusion criteria and are included in this review. Our review suggested that CBFv and/or vasomotor reactivity maybe influenced by rTMS dosage (intensity and frequency) and the type of tDCS electrode montage.

Conclusion

There is limited evidence regarding the effects of NIBS on cerebral hemodynamics using TCD and the usefulness of TCD to capture changes in CBFv after NIBS is not evident from this review. We highlight the variability in the experimental protocols, differences in the applied neurostimulation protocols and discuss open questions that remain regarding CBF and neuromodulation.

Significance

TCD, a clinically accessible tool, may potentially be useful to understand the interaction between cortical neuromodulation and CBFv.

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