Differences in glucose metabolism among women with spinal cord injury may not be fully explained by variations in body composition

Publication date: Available online 12 October 2018

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Jia Li, Gary R. Hunter, Yuying Chen, Amie McLain, Daniel L. Smith, Ceren Yarar-Fisher

Abstract

Objective

To investigate the differences in glucose metabolism among women with paraplegic, and tetraplegic spinal cord injury (SCI) in comparison to their able-bodied (AB) counterparts after adjusting for differences in body composition.

Design

Cross-sectional study. Following an overnight fast, each participant consumed a 75-g glucose solution for oral glucose tolerance test (OGTT). Blood glucose, insulin, and C-peptide concentrations were analyzed before and 30-, 60-, and 120-minute post-consumption. Insulin sensitivity index (ISI) was estimated using the Matsuda index. Percentage fat mass (%FM) and total body lean mass (TBLM) were estimated using data from dual-energy X-ray absorptiometry. Visceral fat (VF) was quantified using computerized tomography. Outcome measures were compared among groups using ANCOVA with %FM (or VF) and TBLM as covariates.

Setting

Research University

Participants

Women with SCI (tetraplegia: n=8; paraplegia: n=14) and their race-, body mass index- and age-matched AB counterparts (n=20).

Interventions

Not applicable.

Results

At fasting, there was no difference in glucose homeostasis (glucose, insulin, and C-peptide concentrations) among 3 groups of women. In contrast, glucose, insulin, and C-peptide concentrations at OGTT 120 min were higher in women with tetraplegia vs. women with paraplegia and AB women (P < 0.05, adjusted for TBLM and %FM). In addition, women with tetraplegia had lower ISI (P < 0.05, adjusted for TBLM and %FM) vs. AB women. These differences remained after adjusting for VF and TBLM.

Conclusion

Our study confirms that impaired glucose metabolism among women with tetraplegia may not be fully explained by changes in their body composition. Future studies exploring additional factors involved in glucose metabolism are warranted.

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