Ocular torsion responses to electrical vestibular stimulation in Vestibular Schwannoma

Publication date: Available online 8 September 2018

Source: Clinical Neurophysiology

Author(s): Stuart W. Mackenzie, Richard Irving, Peter Monksfield, Raghu Kumar, Attila Dezso, Raymond F. Reynolds

Abstract

Objectives

We determined if eye movements evoked by Electrical Vestibular Stimulation (EVS) can be used to detect vestibular dysfunction in patients with unilateral vestibular schwannoma (VS).

Methods

Ocular torsion responses to monaural sinusoidal EVS currents (± 2mA, 2Hz) were measured in 25 patients with tumours ranging in size from Koos grade 1 to 3. For comparative purposes we also measured postural sway response to EVS, and additionally assessed vestibular function with the lateral Head Impulse Test (HIT). Patient responses were compared to age-matched healthy control subjects.

Results

Patients exhibited smaller ocular responses to ipsilesional versus contralesional EVS, and showed a larger asymmetry ratio (AR) than control subjects (19.4 vs. 3.3%, p<0.05). EVS-evoked sway responses were also smaller in ipsilesional ear, but exhibited slightly more variability than the eye movement response, along with marginally lower discriminatory power (patients vs. controls: AR=16.6 vs 2.6%, p<0.05). The HIT test exhibited no significant difference between groups.

Conclusions

These results demonstrate significant deficits in the ocular torsion response to EVS in VS patients.

Significance

The fast, convenient and non-invasive nature of the test are well suited to clinical use.

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