Identifying mild-moderate Parkinson’s disease using whole-brain functional connectivity

Parkinson's disease (PD) is the second most common progressive neurodegenerative disease and is associated predominantly with motor symptoms, such as bradykinesia, in combination with rigidity and resting tremors. Moreover, PD is related to numerous non-motor symptoms, such as mood disorders and cognitive changes (Chaudhuri et al., 2009), some of which precede the motor dysfunction by more than a decade. The current diagnosis of PD is largely based on self-reported symptoms and clinical assessments (Jankovic, 2008) and has a high rate of misdiagnosis (Hughes et al., 1992).

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