Effect of subthalamic nucleus deep brain stimulation on visual scanning

Publication date: Available online 30 August 2018

Source: Clinical Neurophysiology

Author(s): Shin-ichi Tokushige, Shunichi Matsuda, Genko Oyama, Yasushi Shimo, Atsushi Umemura, Takuya Sasaki, Satomi Inomata-Terada, Akihiro Yugeta, Masashi Hamada, Yoshikazu Ugawa, Shoji Tsuji, Nobutaka Hattori, Yasuo Terao

Abstract

Objective

Deep brain stimulation (DBS) can provide insights into the workings of the basal ganglia (BG) by interfering with their function. In patients with Parkinson's disease (PD) treated with DBS of the subthalamic nucleus, we studied the effect of DBS on scanning eye movements.

Methods

In the visual memory task, subjects viewed images of various complexities for later recall. In visual search tasks, subjects looked for and fixated one odd target ring, embedded among 48 Landolt rings, which either stood out or not from the distractors. We compared the parameters of scanning saccades when DBS was on and off.

Results

In the visual memory task, DBS increased the amplitude of saccades scanning simple but not complex drawings. In the visual search tasks, DBS showed no effect on saccade amplitude or frequency.

Conclusions

Saccades when viewing simple images were affected by DBS since they are internally guided saccades, for which the involvement of BG is large. In contrast, saccades when viewing complex images or during visual search, made with the help of visual cues in the images (externally guided saccades) and less dependent on BG, were resistant to the effect of DBS.

Significance

DBS affects saccades differentially depending on the task.

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