Allogeneic mesenchymal stromal cells for refractory luminal Crohn’s disease: A phase I–II study

Crohn's disease (CD) is a complex chronic relapsing disease involving abnormal systemic and mucosal immune responses against intraluminal antigens, favoured by microbial factors and alteration of the mucosal barrier. A key role in its pathogenesis is played by the imbalance between proinflammatory T helper (Th)1/Th17 cells and regulatory T lymphocytes (Treg), resulting in activation of macrophages and B cells, and recruitment of circulating leukocytes into the gut. Mesenchymal stromal cells (MSCs) exert potent immunomodulatory effects and exhibit interesting properties for tissue repair [1].

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