Concentrating on intrinsic disorder

Concentrating on intrinsic disorder

Concentrating on intrinsic disorder, Published online: 16 July 2018; doi:10.1038/s41576-018-0037-7

Many eukaryotic proteins, including key transcription regulators, contain intrinsically disordered regions (IDRs), which serve as flexible interaction platforms. The molecular understanding of IDR-based interactions is now emerging, providing new insights into how IDRs promote protein compartmentalization and/or phase separation and how these processes regulate gene expression.

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