Attenuation of the degenerative effects of endothelin-1 on cartilaginous endplate cells by the endothelin receptor antagonist BQ-123 via the wnt/β-catenin signaling pathway

Context: Endothelin-1 (ET-1) is an inflammatory mediator associated with cartilage endplate (CEP) degeneration in the intervertebral disc. SOX9 is down-regulated during CEP degeneration, along with its targets, collagen II and aggrecan. Wnt/β-catenin signaling is associated with CEP degeneration and a downstream target of SOX9; however, the precise mechanism of CEP degeneration and the role of ET-1 are largely unknown.

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