A controlled clinical trial on the effects of exercise on cognition and mobility in adults with multiple sclerosis

Objective To investigate the effects of a 6-month exercise program on cognition and mobility in participants with multiple sclerosis. Design Prospective, single blind, controlled clinical trial. Setting A community rehabilitation program within a large metropolitan health service. Participants Twenty-eight patients with multiple sclerosis, referred for outpatient rehabilitation. Interventions Participants were allocated to one of two groups and undertook a cognitive-motor exercise program or monitoring (control group). Main outcome measures Cognition and mobility. Cognition was evaluated using the Mini-Mental State Examination and the Frontal Assessment Battery. Mobility was assessed with the Timed Get-Up-and-Go-Test, applied with and without dual task distractors. Results The findings showed benefits provided by exercise on cognition and mobility. Differently, participants of the control group did not have significant changes in cognition scores after 6 months of follow-up, and had a worse performance in mobility tests. Conclusion Six months of exercise provided benefits to cognition and mobility in adults with multiple sclerosis. This trial was registered prospectively with the Brazilian Clinical Trials Register, ID: RBR-9gh4km, (https://ift.tt/2tsqhM3). All correspondence and requests for reprints should be addressed to: Gustavo Christofoletti, PhD, Institute of health, Universidade Federal de Mato Grosso do Sul, Av. Universitária, s/n, Caixa Postal 549, Campo Grande, MS, Brazil. Email: g.christofoletti@ufms.br Clinical Trial Identifier: RBR-9gh4km (https://ift.tt/2tsqhM3) Conflicts of interest: none. Financial disclosures: none. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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