Small fibre neuropathy in mitochondrial diseases explored with sudoscan

Peripheral nervous system (PNS) is highly dependent on energy metabolism, and consequently, mitochondrial dysfunction can contribute to peripheral neuropathy. In fact, mitochondria play a key role in the pathophysiology of the PNS for the involvement in the release of energy in the form of ATP to maintain ionic gradients, preserve the integrity of axonal cytoskeletal elements, transport cellular components along the extended lengths of axons, sustain of exocytosis/recycling of synaptic vesicles at axonal terminals, and for the regulation of the Ca2+ homeostasis (Persson et al., 2016).

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