Τρίτη 1 Μαΐου 2018

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers [Genetics]

ATRX (alpha thalassemia/mental retardation X-linked) complexes with DAXX to deposit histone variant H3.3 into repetitive heterochromatin. Recent genome sequencing studies in cancers have revealed mutations in ATRX and their association with ALT (alternative lengthening of telomeres) activation. Here we report depletion of ATRX in mouse ES cells leads to selective...

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