Rapid Eye Movement Sleep Behavior Disorder and the Link to Alpha-Synucleinopathies

Rapid eye movement (REM) sleep, which occupies approximately 20-25% of total sleep time, is a cyclical sleep state, occurring in intervals of 90-120 minutes during the night. Normally, during REM sleep, there is active inhibition of motor activity, which results in complete or near- complete muscle atonia. Atonia results from an interplay of multiple neurotransmitter systems, with a decrease in excitatory activity and increase in the inhibitory glycinergic and GABAergic premotor neuronal input to motor neurons.

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