Controlling nuclear RNA levels

Controlling nuclear RNA levels

Controlling nuclear RNA levels, Published online: 10 May 2018; doi:10.1038/s41576-018-0013-2

RNA is controlled at various stages of transcription and processing to achieve appropriate gene regulation. Whereas much research has focused on the cytoplasmic control of RNA levels, this Review discusses our emerging appreciation of the importance of nuclear RNA regulation, including the molecular machinery involved in nuclear RNA decay, how functional RNAs bypass degradation and roles for nuclear RNA decay in physiology and disease.

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