Purpose Heat illnesses are important and potentially fatal conditions among physically active individuals. We determined predictors of heat illness among enlistees in a large military population experiencing common physical activity patterns. Methods We estimated the adjusted odds of mild and severe heat illness associated with demographic, health-related, and geographic factors among active-duty, United States Army soldiers enlisting between January 2011 – December 2014 (N=238,168) using discrete-time multivariable logistic regression analyses. Results We observed 2,612 incident cases of mild heat illness (MHI) and 732 incident cases of severe heat illness (SHI) during 427,922 person-years of follow-up, with a mean and median of 21.6 and 21 months per subject. During the first six duty months, 71.3% of the MHIs and 60.2% of the SHIs occurred, peaking at month two. The odds of MHI quadrupled among those with prior SHI (OR=4.02, 95% confidence interval [CI]: 2.67 – 6.03). Body mass index (BMI) extremes increased risk substantially (ORs at BMI ≥30: for MHI, 1.41, CI 1.19 – 1.67; for SHI, 1.94, CI 1.47 – 2.56; ORs at BMI
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