The efficacy of transcranial random noise stimulation (tRNS) on mood may depend on individual differences including age and trait mood

Publication date: June 2018
Source:Clinical Neurophysiology, Volume 129, Issue 6
Author(s): Carys Evans, Michael J. Banissy, Rebecca A. Charlton
ObjectivesTo assess whether changes in brain microstructures associated with ageing and presence of cardiovascular risk factors (CVRF) reduce the efficacy of transcranial electrical stimulation (tES) improving mood in euthymic older adults.MethodsUsing excitatory high-frequency transcranial random noise stimulation (tRNS) over bilateral dorsolateral prefrontal cortex, the effect on mood was assessed in euthymic young adults (YA), older adults (HOA) and older adults with CVRF (OVR). Active-tRNS or sham was applied over two sessions. Positive and Negative Affect Schedule and Warwick Edinburgh Mental Well-being Scale measured self-reported state mood before and after stimulation. Trait mood was also measured using the Geriatric Depression Scale.ResultsResponse to tRNS seemed dependent on individual differences in age and trait mood. In HOA, more negative trait mood was associated with more positive mood change after tRNS. OVR showed a similar but reduced pattern of mood change to HOA. In YA, more positive trait mood was associated with greater positive mood change after tRNS.ConclusionsAge and trait mood may be important factors when examining the efficacy of tES as an alternative treatment for depression.SignificanceFuture studies should consider how response to tES is affected by individual differences.



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