Anemia in Pediatric Inflammatory Bowel Disease

Objectives: Anemia is the most frequent extra-intestinal finding in Inflammatory Bowel Disease. The aim of this study is to determine the prevalence and types of anemia in pediatric patients with Inflammatory Bowel Disease at diagnosis and at approximately one year follow up. Methods: This is a retrospective chart review of patients diagnosed with Inflammatory Bowel Disease from 2005 to 2012, ages 1-18 years. Patients who had hemoglobin, hematocrit, mean corpuscular volume and iron indices obtained at the time of diagnosis and at approximately one year follow up were included in the study. The prevalence of anemia at the beginning and the end of the study was recorded. Using the soluble transferrin receptor index the type of anemia was determined. Results: At diagnosis, 67.31% of patients were anemic. Overall, 28.85% of patients had either Iron deficiency anemia or a combination of Iron deficiency anemia and anemia of chronic disease, while 38.46% had anemia of chronic disease alone. At follow up 20.51% were anemic. 15.38% had either iron deficiency anemia or a combination of iron deficiency anemia and anemia of chronic disease; 5.13% had anemia of chronic disease alone. The pattern of anemia and response to therapy differed among the inflammatory Bowel disease phenotypes Conclusion: Anemia is frequent in Inflammatory Bowel Disease. The prevalence was higher in Crohn's Disease. At one year, the prevalence of anemia decreased significantly, but persisted. Anemia of Chronic Disease predominated in CD. Iron Deficiency Anemia continued to be present in CD and UC. Address correspondence and reprint requests to Robert D. Baker, Digestive Diseases and Nutrition Center, Women and Children's Hospital of Buffalo, 219 Bryant Street, Buffalo, NY 14222, Tel: +716 878 7793; fax: +716 888 3842;(e-mail: rbaker@upa.chob.edu). Received 14 August, 2017 Accepted 11 January, 2018 There was no outside funding for this research. Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org). © 2018 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

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