Systemic effects of deep brain stimulation on synergic control in Parkinson’s disease

Deep brain stimulation (DBS) of nuclei within the basal ganglia, typically the subthalamic nucleus and globus pallidus, has been used as an effective treatment of Parkinson's disease (PD), commonly in combination with dopamine-replacement medications (reviewed in Kalia et al., 2013; DeLong and Wichmann, 2015). Many studies have reported significant positive effects of DBS on clinical indices such as Unified Parkinson's Disease Rating Scale (UPDRS) scores and general characteristics of movements such as maximal force, peak velocity, and movement time (Brown et al., 1999; Alberts et al., 2008; Daneault et al., 2016).

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