Τρίτη 27 Μαρτίου 2018

Requirement for intron structures in activating the Cd8a locus [Genetics]

During differentiation of CD4+CD8+ double-positive (DP) thymocytes into the CD4−CD8+ single-positive (CD8SP) thymocytes committed to the cytotoxic T cell lineage, Cd8a transcription is temporally terminated after positive selection and is subsequently reinitiated, a process known as coreceptor reversal. Despite the identification of a transcriptional enhancer in the Cd8a gene that...

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