Τρίτη 13 Μαρτίου 2018

Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema [Genetics]

Chronic obstructive pulmonary disease affects 10% of the worldwide population, and the leading genetic cause is α-1 antitrypsin (AAT) deficiency. Due to the complexity of the murine locus, which includes up to six Serpina1 paralogs, no genetic animal model of the disease has been successfully generated until now. Here we...

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