The role of STIM proteins in neutrophil functions

Abstract

STIM proteins regulate store-operated Ca²⁺ entry (SOCE) in innate and adaptive immune cells and participate to the Ca²⁺ signals that control the functions of neutrophils, the first line of host defence against bacterial and fungal infections. Loss of function experiments in animal and cellular models indicate that both STIM1 and STIM2 regulate neutrophil functions, but the complexity of the SOCE machinery and the versatility of neutrophils complicate the evaluation of the results. This review aims to summarize the latest progress in the field with a special attention to the details of the experimental designs. Future study design should aim to improve the standardization of experimental procedures and to provide a more holistic understanding of the role of STIM proteins in neutrophils function.

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