Tandem repeats mediating genetic plasticity in health and disease

Tandem repeats mediating genetic plasticity in health and disease

Tandem repeats mediating genetic plasticity in health and disease, Published online: 05 February 2018; doi:10.1038/nrg.2017.115

DNA repeats are more liable to mutation than other genetic variants, which enables them to mediate genetic plasticity. The expansion of tandem repeats can cause a range of monogenic disorders, contribute to the missing heritability of polygenic disorders and regulate gene expression, as well as RNA and protein function, in healthy individuals.

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