Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer

Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer

Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer, Published online: 26 February 2018; doi:10.1038/nrg.2018.9

Adult stem cells are essential for the maintenance of tissue homeostasis and wound repair, but cancer can hijack their tissue regenerative functions to promote malignancy. Ge and Fuchs review recent insights into the determinants and general principles underlying stem cell plasticity under homeostasis, stress and cancer.

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