Reply to “Is it significant? Is it relevant?”

We thank Drs. Manca and Deriu for their insightful comments (Manca and Deriu, 2018). We agree that the scientific and clinical relevance of a study is not necessarily reflected by the statistical significance of a specific test. A statistical cut-off, using a pre-defined significance threshold, should not be equated with the presence or absence of a scientifically or clinically relevant finding. Judging the scientific or clinical relevance requires more than simply referring to statistical significance.

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