Παρασκευή 9 Φεβρουαρίου 2018

Nonsense-mediated mRNA decay factors cure most [PSI+] prion variants [Genetics]

The yeast prion [PSI+] is a self-propagating amyloid of Sup35p with a folded in-register parallel β-sheet architecture. In a genetic screen for antiprion genes, using the yeast knockout collection, UPF1/NAM7 and UPF3, encoding nonsense-mediated mRNA decay (NMD) factors, were frequently detected. Almost all [PSI+] variants arising in the absence of...

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