Capicua (CIC) regulates a transcriptional network downstream of the RAS/MAPK signaling cascade. In Drosophila, CIC is important for many developmental processes, including embryonic patterning and specification of wing veins. In humans, CIC has been implicated in neurological diseases, including spinocerebellar ataxia type 1 (SCA1) and a neurodevelopmental syndrome. Additionally, we...
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Τρίτη 13 Φεβρουαρίου 2018
Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma [Genetics]
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