Large inter-rater variability on EEG-reactivity is improved by a novel quantitative method

EEG-reactivity (EEG-R) has been defined as a change in EEG activity to stimulation (Hirsch et al., 2013). The most well-known type of EEG-R is the blocking of alpha activity to eye opening, which is most often present in healthy subjects. EEG-R is regarded as an important prognostic marker in comatose patients. In several studies, EEG-R predicts the comatose patient's awakening and recovery. This has been shown in patients with cardiac arrest (Wennervirta et al., 2009; Crepeau et al., 2013; Sandroni et al., 2013), after severe brain injury (Logi et al., 2011) and in ICU patients who are comatose due to anoxia, trauma, metabolic or infectious diseases (Young et al., 1999).

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