Home-based neuromuscular electrical stimulation as an add-on to pulmonary rehabilitation does not provide further benefits in patients with chronic obstructive pulmonary disease: A multicenter randomized trial

Publication date: Available online 16 February 2018
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Tristan Bonnevie, Francis-Edouard Gravier, David Debeaumont, Catherine Viacroze, Jean-François Muir, Antoine Cuvelier, Marie Netchitaïlo, Anne Laure Roy, Jean Quieffin, Marie-Hélène Marques, Clément Médrinal, Johan Dupuis, Catherine Tardif
ObjectiveTo assess the additional effect of a home-based neuro muscular electrical stimulation (NMES) program as an add-on to pulmonary rehabilitation (PR), on functional capacity in subjects with chronic obstructive pulmonary disease (COPD).DesignSingle-blind, multicenter randomized trial.SettingThree PR centers.ParticipantsSubjects with severe to very severe COPD referred for PR (n=73; median FEV1, 1 (0.8-1.4) L). Twenty-two subjects discontinued the study but only one drop-out was related to the intervention (leg discomfort).InterventionSubjects were randomly assigned to either PR plus quadricipital home-based NMES (35Hz, 30min, five time per week) or PR without NMES for 8 weeks.Main outcome measureThe six-minute walk test was used to assess functional capacity.ResultsEighty-two percent of the scheduled NMES sessions were performed. In the whole sample, there were significant increases in the distance walked during the 6MWT (p<0.01), VO2peak (p=0.02), Wmax (p<0.01), mMRC (p<0.01) and SGRQ total score (p=0.01). There was no significant difference in the magnitude of change for any outcome between groups.ConclusionsHome-based NMES as an add-on to PR did not result in further improvements in subjects with severe to very severe COPD, moreover, it may have been a burden for some patients.



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