Effect of exercise intensity on circulating microparticles in men and women

Abstract

Circulating microparticles (MPs) are biological vectors of information within the cardiovascular system, eliciting both deleterious and beneficial effects on the vasculature. Acute exercise has been shown to alter MP concentrations, likely through a shear stress-dependent mechanism, however evidence is limited. Therefore, we investigated the effect of exercise intensity on plasma levels of CD34⁺ and CD62E⁺ MPs in young, healthy men and women. Blood samples were collected before, during, and after two energy-matched bouts of acute treadmill exercise: interval exercise (10 × 1-minute intervals at ∼95% VO_2max) and continuous exercise (65% VO_2max). Continuous exercise, but not interval, reduced CD62E⁺ MP concentrations in men and women by 18% immediately after exercise (from 914.5 ± 589.6 MPs μL⁻¹ to 754.4 ± 390.5 MPs μL⁻¹, P < 0.05), suggesting that mechanisms underlying exercise-induced CD62E⁺ MP dynamics are intensity dependent. Furthermore, continuous exercise reduced CD62E⁺ MPs in women by 19% (from 1030.6 ± 688.1 MPs μL⁻¹ to 829.9 ± 435.4 MPs μL⁻¹, P < 0.05), but not men. While interval exercise did not alter CD62E⁺ MPs per se, the concentrations after interval exercise were higher than that observed after continuous exercise (p < 0.05). Conversely, CD34⁺ MPs did not fluctuate in response to short-duration acute continuous or interval exercise in men or women. Our results suggest that exercise-induced MP alterations are intensity dependent, sex-specific, and differentially impact MP populations.

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