Lower quadriceps rate of force development is associated with worsening physical function in adults with or at risk for knee osteoarthritis: 36-month follow-up data from the Osteoarthritis Initiative

Publication date: Available online 31 January 2018
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Bo Hu, Søren Thorgaard Skou, Barton L. Wise, Glenn N. Williams, Michael C. Nevitt, Neil A. Segal
ObjectiveThe purpose of this study was to determine the association between quadriceps rate of force development (RFD) and decline in self-reported physical function and objective measures of physical performance.DesignLongitudinal cohort studySettingCommunity-based sample from 4 urban areasParticipantsOsteoarthritis Initiative participants with or at risk for knee OA, who had no history of knee/hip replacement, knee injury, or rheumatoid arthritis (N=2630).InterventionsNot applicable.Main Outcome Measure(s)Quadriceps RFD (N/sec) was measured during isometric strength testing using the Good Strength chair. Worsening physical function was defined as the Minimal Clinically Important Difference for worsening self-reported WOMAC physical function (WOMAC-PF) score, 20-meter walk time, and repeated chair stand time over 36 months.ResultsCompared to the slowest tertile of RFD, the fastest tertile had lower risk for worsening of WOMAC-PF at 36-month follow-up, with an odds ratio (OR, 95%CI) of 0.68 (0.51, 0.92) after adjustment for age, sex, BMI, depression, history of chronic diseases, and knee pain. In women, in comparison with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC-PF at 36-month follow-up, with an adjusted OR of 0.57 (0.38, 0.86). This decreased risk did not reach statistical significance in men (OR 0.81 (0.52, 1.27)). No statistically significant associations were detected between baseline RFD and walk or chair stand times.ConclusionsOur results indicate that higher quadriceps rate of force development is associated with decreased risk for worsening self-reported physical function but not with decreased risk for worsening of physical performance.



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