Cancer has been shown to negatively stimulate autophagy, leading to declines in cardiac function. While exercise is cardioprotective, its influence over autophagy-mediated tumor growth and cardiac function are not well defined. Purpose: To determine the effect of exercise on tumor morphology and cardiac function. Methods: Fisher 344 rats (n=28) were assigned to one of four groups: 1) sedentary non tumor-bearing (SED), 2) sedentary tumor-bearing (SED+T), 3) wheel run non-tumor bearing (WR), or 4) wheel running tumor bearing (WR+T). Rats remained sedentary or exercised for 6 weeks. At week 4, rats in tumor groups were inoculated with MatBIII tumor cells (flank). At week 6, cardiac function was measured. Results: SED+T animals exhibited significantly lower left ventricular developed pressure when compared to SED, WR, and WR+T (P
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