Prostate Cancer and the Evolving Role of Biomarkers in Screening and Diagnosis

Publication date: Available online 26 November 2017
Source:Radiologic Clinics of North America
Author(s): Joseph F. Rodriguez, Scott E. Eggener

Teaser

The diagnosis and management of prostate cancer have substantially changed over the last 3 decades. Serum prostate-specific antigen (PSA) was adopted for screening in the 1990s after it was found to be a sensitive indicator of disease. Because of a lack of specificity for significant disease, indiscriminate PSA testing led to overdiagnosis and overtreatment. Several biomarkers have been developed that are superior to PSA in stratifying a man's risk for harboring potentially lethal prostate cancer.


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