Influence of age and gender on the phase and strength of the relation between heart period and systolic blood pressure spontaneous fluctuations

Aging affects baroreflex regulation. The effect of senescence on baroreflex control was assessed from spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) through the HP-SAP gain, while the HP-SAP phase and strength are usually disregarded. This study checks whether the HP-SAP phase and strength, as estimated respectively via the phase of the HP-SAP cross-spectrum (Ph_HP-SAP) and squared coherence function (K²_HP-SAP), varies with age in healthy individuals and trends are gender-dependent. We evaluated 110 healthy volunteers (55 males) divided into five age subgroups (21-30; 31-40; 41-50; 51-60; 61-70 yr). Each subgroup was formed by 22 subjects (11 males). HP series was extracted from electrocardiogram and SAP from finger arterial pressure at supine resting (REST) and during active standing (STAND). PhHP-SAP and K²_HP-SAP functions were sampled in low frequency (LF, from 0.04 to 0.15 Hz) and in high frequency (HF, above 0.15 Hz) bands. Both at REST and during STAND Ph_HP-SAP(LF) showed a negative correlation with age regardless of gender even though values were more negative in women. This trend was shown to be compatible with a progressive increase of the baroreflex latency with age. At REST K²_HP-SAP(LF) decreased with age regardless of gender but during STAND the high values of K²_HP-SAP(LF) were more preserved in men than women. At REST and during STAND the association of Ph_HP-SAP(HF) and K²_HP-SAP(HF) with age was absent. The findings points to a greater instability of baroreflex control with age that seems to affect to a greater extent women than men.

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