High-Intensity Exercise Enhances Conduit Artery Vascular Function in Older Adults

ABSTRACTPurposeModulation of vascular function follows an exercise intensity–dependent pattern in young adults. This study aimed to investigate the potential intensity–dependent effects of an acute bout of exercise on conduit and resistance artery function in healthy older adults.MethodsEleven healthy older adults (five males/six females, 66 ± 1 yr) completed 30 min of recumbent cycling at 50%–55% (low intensity) and 75%–80% (high intensity) of their age-predicted HRmax on two separate study visits. Doppler ultrasound measures of brachial artery flow-mediated dilation (FMD) and reactive hyperemia were taken at baseline, 10 min postexercise, and 1 h postexercise. In addition, cardiovascular hemodynamics and brachial shear rate were measured every 5 min during exercise.ResultsBrachial artery FMD was enhanced 10 min after high-intensity exercise (4.8% ± 0.2% to 9.1% ± 0.3%, P 0.05).ConclusionOur data indicate that high-intensity exercise acutely enhances conduit artery function in healthy older adults. In addition, an acute bout of exercise enhances resistance artery function independent of intensity. Purpose Modulation of vascular function follows an exercise intensity–dependent pattern in young adults. This study aimed to investigate the potential intensity–dependent effects of an acute bout of exercise on conduit and resistance artery function in healthy older adults. Methods Eleven healthy older adults (five males/six females, 66 ± 1 yr) completed 30 min of recumbent cycling at 50%–55% (low intensity) and 75%–80% (high intensity) of their age-predicted HRmax on two separate study visits. Doppler ultrasound measures of brachial artery flow-mediated dilation (FMD) and reactive hyperemia were taken at baseline, 10 min postexercise, and 1 h postexercise. In addition, cardiovascular hemodynamics and brachial shear rate were measured every 5 min during exercise. Results Brachial artery FMD was enhanced 10 min after high-intensity exercise (4.8% ± 0.2% to 9.1% ± 0.3%, P 0.05). Conclusion Our data indicate that high-intensity exercise acutely enhances conduit artery function in healthy older adults. In addition, an acute bout of exercise enhances resistance artery function independent of intensity.

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