Genetic architecture: the shape of the genetic contribution to human traits and disease

Genetic architecture: the shape of the genetic contribution to human traits and disease

Genetic architecture: the shape of the genetic contribution to human traits and disease, Published online: 11 December 2017; doi:10.1038/nrg.2017.101

Genetic architecture describes the characteristics of genetic variation that are responsible for phenotypic variability. This Review discusses the types of genetic architecture that have been observed, how they can be measured and how genetic architecture informs the scientific and clinical goals of human genetics.

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