Differential changes in the spinal segmental locomotor output in Hereditary Spastic Paraplegia

Hereditary spastic paraplegia (HSP) includes a heterogeneous group of inherited neurodegenerative disorders resulting from primary retrograde degeneration of corticospinal fibers originating from many areas of the brain (de Souza et al., 2016). Most of the corticospinal neurons originate in the primary motor cortex and premotor frontal areas. Corticospinal axons originating from layer V pyramidal neurons synapse directly or via spinal interneurons with alpha-motor neurons (MN) innervating skeletal muscles and controlling movements of the limbs and trunk.

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