Case Series: Slowing Alpha Rhythm in Late-Stage ALS Patients

To this date, the cognitive abilities of patients in the final stage of Amyotrophic Lateral Sclerosis (ALS) are largely unknown. Residing in a completely locked-in state (CLIS) makes interaction by regular means impossible. Many attempts were made to establish communication through Brain-computer interfaces (BCIs), but success has been very limited (Marchetti and Priftis, 2015). It has been theorized that the loss of motor-functions leads to an extinction of both goal directed thinking and physiological control, leaving only reflex-like responses to fundamental, personal questions (Gallegos-Ayala et al., 2014; Chaudhary et al., 2017).

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