What is the optimal frequency range for quantifying slow EEG activity in neonates? Insights from power spectra

Several weeks before and following term age, intermittent anterior slow waves in the delta frequency range (<4 Hz) are a normative neonatal EEG feature (e.g., Clancy et al., 2014; Fig.1A). Various quantitative electroencephalographic (qEEG) studies of infants born preterm have analyzed relative power of delta and other frequency bands. For example, across 60 healthy infants born at 26-41 weeks and assessed with EEG on the third day, Bell et al. (1991) reported gestational age (GA) was negatively correlated with relative "lower-delta" (0.25-1 Hz) power.

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