Vitamin B1 Deficiency Related to Excessive Soft Drink Consumption in Japan

ABSTRACT The aim of this study was to clarify the picture of vitamin B1 deficiency (VB1D) caused by excessive soft drink consumption in Japan. A nationwide survey of children with soft drink-induced VB1D was conducted using a structured research form. Patient information was obtained from two sources: training hospitals for board-certified pediatricians and those identified by a database search. We obtained data from 33 children. Twenty-one children had a non-nurturing home environment. The median duration of excessive soft drink intake was 3.5 months and the daily intake was 1,000 mL or more in 25 children. Infection was the most common reason for excessive soft drink consumption. Only four children had the classical triad of Wernicke encephalopathy. One child died, and twelve had neurological sequelae. A majority of children with soft drink-induced VB1D did not have a nurturing home environment. It is imperative to establish measures to prevent future cases of VB1D. Address correspondence and reprint requests to Akihisa Okumura, MD, PhD, Department of Pediatrics, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195 Japan (e-mail: okumura.akihisa.479@mail.aichi-med-u.ac.jp). Received 8 August, 2017 Accepted 15 November, 2017 Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org). Conflicts of Interest and sourses of funding: MM has received lecture fees from MSD K.K and Accvie LLC, and received consulting fees from Daiichi Sankyo Co., Ltd. And Taisho Pharmaceutical Co., Ltd. The other authors have no competing interests relevant to this article to disclose. This study was supported by the Japanese Pediatric Society. The other authors report no conflicts of interest. © 2017 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

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