Statistical and integrative system-level analysis of DNA methylation data

Statistical and integrative system-level analysis of DNA methylation data

Statistical and integrative system-level analysis of DNA methylation data, Published online: 13 November 2017; doi:10.1038/nrg.2017.86

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The wealth of DNA methylation data continues to grow rapidly, including from epigenome-wide association studies (EWAS). However, extracting meaningful biological and clinical information requires diverse computational approaches for data analysis. This Review discusses the range of statistical tools available, including for cell-type deconvolution, identification of important methylation data features, causation and system-level integration with other types of omic data.

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