Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda.

Objective: To determine sucralose and acesulfame-K pharmacokinetics in breast milk following maternal ingestion of a diet soda. Methods: Thirty-four exclusively breastfeeding women (14 normal weight, 20 obese) consumed twelve ounces of Diet Rite Cola(TM), sweetened with 68 mg sucralose and 41 mg acesulfame-potassium, prior to a standardized breakfast meal. Habitual LCS intake was assessed via a diet questionnaire. Breast milk was collected from the same breast prior to beverage ingestion and hourly for six hours. Results: Due to one mother having extremely high concentrations, peak sucralose and acesulfame-potassium concentrations following ingestion of diet soda ranged from 4.0-7,387.9 ng/mL (median peak 8.1 ng/mL) and 299.0 - 4764.2 ng/mL (median peak 945.3 ng/mL), respectively. Conclusions: Ace-K and sucralose transfer into breast milk following ingestion of a diet soda. Future research should measure concentrations after repeated exposure and determine whether chronic ingestion of sucralose and acesulfame-potassium via the breast milk has clinically relevant health consequences. Clinical Trial Registration: NCT #02940795. (C) 2017 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

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