Exercise-induced Protein Arginine Methyltransferase Expression in Skeletal Muscle.

Purpose: This study aimed to determine protein arginine methyltransferase 1 (PRMT1), -4 (also known as coactivator-associated arginine methyltransferase 1; CARM1), and -5 expression and function during acute, exercise-induced skeletal muscle remodelling in vivo. Methods: C57BL/6 mice were assigned to one of three experimental groups: sedentary, acute bout of exercise, or acute exercise followed by 3 hours of recovery. The mice in the exercise groups performed a single bout of treadmill running at 15 m/min for 90 minutes. Hindlimb muscles were collected and quantitative real-time polymerase chain reaction and Western blotting were employed to examine exercise-induced gene expression. Results: PRMT gene expression and global enzyme activity were muscle-specific, generally being higher (P

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