Biological/Genetic Regulation of Physical Activity Level: Consensus from GenBioPAC

ABSTRACT PURPOSE Physical activity unquestionably maintains and improves health; however, physical activity levels globally are low and not rising despite all the resources devoted to this goal. Attention in both the research literature and the public policy domain has focused on social-behavioral factors; however, a growing body of literature suggests that biological determinants play a significant role in regulating physical activity levels. For instance, physical activity level, measured in various manners, has a genetic component in both humans and non-human animal models. This consensus paper, developed as a result of an ACSM-sponsored round table, provides a brief review of the theoretical concepts and existing literature that supports a significant role of genetic and other biological factors in the regulation of physical activity. CONCLUSION Future research on physical activity regulation should incorporate genetics and other biological determinants of physical activity instead of a sole reliance on social and other environmental determinants. Corresponding Author: J. Timothy Lightfoot, Department of Health and Kinesiology, Texas A&M University, College Station, TX, TLightfoot@tamu.edu The results of the present study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. Funding: The authors would like to thank the organizations that provided supporting funds for this Roundtable: The American College of Sports Medicine, The Texas A&M Vice-President of Research office, the Texas A&M Institute for Genome Sciences and Society, The Sydney and JL Huffines Institute of Sports Medicine and Human Performance, and the Omar Smith Endowment. T.G. is supported by NIH/NICHD R21HD084856 and NSF DEB-1655362. M.dH. is supported by project grants from the Swedish Research Council (2015-03657), the Swedish Heart-Lung Foundation (20140543), and NIH (R01DK106236). J.K. is an Academy of Finland funded Research Professor (grants #265240, 263278). Conflict of Interest: The authors report no conflict of interest. The results of the present study do not constitute endorsement by the American College of Sports Medicine. Accepted for Publication: 14 November 2017 © 2017 American College of Sports Medicine

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