Association of the Brain-Derived Neurotrophic Factor and Serotonin Transporter Genes with Parameters of the Early Components of Event-Related Potentials on Passive Word Perception

Associations of genes for the serotonin transporter (the 5-HTTLPR polymorphism) and the brain-derived neurotrophic factor (the BDNF Val66Met polymorphism) with the neurophysiological characteristics at the initial stage of processing lexical information in patients with schizophrenia spectrum disorder and human mental health were studied. Neurophysiological characteristics at the initial stage of processing meaningful verbal information were found to differ in carriers of different variants of the Val66Met and 5-HTTLPR polymorphisms. Word recognition efficiency in implicit conditions was greater in carriers of the ValVal (BDNF Val66Met) or SS (5-HTTLPR) polymorphisms than in carriers of the Met or L variants. Genetic variants were found to have significant effects in mentally healthy people but not in patients with schizophrenia disorders.

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