Stimulus, response and excitability – what is new?

While it is pleasing to read about increasing awareness of the limitations of diagnostic approaches, and concepts of axonal excitability, the question remains whether novel approaches can be devised to offer more than what is currently available. As a case in point, Milants et al. (2017) have measured the lowest stimulus intensity necessary to produce a maximal CMAP (iMAX) from the innervated muscle in healthy subjects and in small cohorts of patients with hereditary and acquired demyelinating disease and in AMAN, and suggest that additional information can come from this measure over and above measurements of the threshold for a liminal CMAP.

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