Exercise training dose differentially alters muscle and heart capillary density and metabolic functions in an obese rat with metabolic syndrome

Abstract

We evaluated the effect of frequency, duration and intensity of exercise training on metabolic parameters and structural capillary density in obese rats with metabolic syndrome (MS). Wistar-Kyoto rats were fed a either standard commercial diet (CON) or high-fat diet (HFD). Animals that received the HFD were randomly separated into either a sedentary (SED) group or 8 different exercise groups that varied by the frequency, duration and intensity of training. After 12 weeks of aerobic exercise training, body composition, aerobic capacity, hemodynamic variables, metabolic parameters and capillary density in the heart and skeletal muscle were evaluated. All of the exercise training groups showed reduced resting systolic blood pressure and heart rate, and normalized fasting glucose. The minimum amount of exercise (90 min week⁻¹) produced little effect on MS parameters. A moderate amount of exercise (150 min week⁻¹) was required to reduce body weight and improve capillary density. However, only the high amount of exercise (300 min week⁻¹) significantly reduced the amount of body fat depots. The three-way ANOVA analysis showed a main effect of exercise frequency and duration for the improvement of MS and capillary density in skeletal muscle. Exercise intensity was a main factor in reversing microvascular rarefaction in the heart.

This article is protected by copyright. All rights reserved

from Physiology via xlomafota13 on Inoreader http://ift.tt/2fLfGJq
via IFTTT