Does pharmacokinetic/pharmacodynamic model-guided anaesthesia improve outcome after hip fracture surgery?

Hip fracture affects ∼628 000 patients annually and accounts for ∼200 000 deaths in Europe.¹ The EuroHOPE database, which includes seven European countries, revealed that the 30 day mortality rate after hip fracture surgery ranges from 4 to 12% and reaches up to 35% after 1 yr.² Postoperative complications, such as serious cardiac and pulmonary events, appear most frequently.¹³ Postoperative delirium occurs often and is associated with increased mortality.⁴ Improving outcomes for vulnerable elderly hip-fractured patients is a key goal for perioperative care.¹

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