Τρίτη 5 Σεπτεμβρίου 2017

Stalled replication forks generate a distinct mutational signature in yeast [Genetics]

Proliferating cells acquire genome alterations during the act of DNA replication. This leads to mutation accumulation and somatic cell mosaicism in multicellular organisms, and is also implicated as an underlying cause of aging and tumorigenesis. The molecular mechanisms of DNA replication-associated genome rearrangements are poorly understood, largely due to methodological...

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