Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol [Genetics]

Risk, severity, and outcome of infection depend on the interplay of pathogen virulence and host susceptibility. Systematic identification of genetic susceptibility to infection is being undertaken through genome-wide association studies, but how to expeditiously move from genetic differences to functional mechanisms is unclear. Here, we use genetic association of molecular,...

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